Phenanthrenes and derivatives
Apexbio Technology LLC IM-12 1129669-05-1 200mg
IM-12 (CAS 1129669-05-1) is a small-molecule inhibitor targeting glycogen synthase kinase-3 (GSK-3 ) displaying an IC50 of 53 nM GSK-3 is a serine/threonine kinase involved in neuronal development energy metabolism and Wnt/ -catenin signaling In ReNcell VM cells IM-12 inhibits GSK-3 resulting in increased -catenin accumulation enhanced TCF transcriptional activity and elevated neuronal differentiation markers The compound also extends cell doubling time and suppresses proliferation These properties make IM-12 valuable for investigating GSK-3 signaling in neurobiology cell proliferation and differentiation studies
TARGETMOL CHEMICALS INC Aristolochic acid A 100MG
Also available in 1 mL, 10 mg, 25 mg, 50 mg, 500 mg and bulk. Please contact Fisher for quotes. Aristolochic acid A (TR 1736) is a compound of mutagenic, carcinogenic, and nephrotoxic compounds commonly found in the Birthwort (Aristolochiaceae) family of plants. Purity 99.97%
Apexbio Technology LLC Caffeic acid 331-39-5 200mg
Caffeic acid (CAS 331-39-5) is a naturally occurring hydroxycinnamic acid extracted from plant sources such as Solidago decurrens and large-fruited Chinese hawthorn This small molecule is known for its antioxidant activity primarily through the scavenging of reactive oxygen species and inhibition of lipid peroxidation Caffeic acid has also been reported to modulate various cellular signaling pathways including those related to inflammation and apoptosis Due to its bioactive properties caffeic acid is widely utilized in biomedical research to investigate mechanisms of oxidative stress inflammation and associated cellular events It is soluble in hot water and cold ethanol and should be stored sealed in cool dry conditions
Medchemexpress LLC Hypericin | 548-04-9 | 504.443 | 1 MG
Hypericin is a naturally occurring substance found in Hypericum perforatum L. It functions as an inhibitor of PKC (protein kinase C), MAO (monoaminoxidase), dopamine-beta-hydroxylase, reverse transcriptase, telomerase, and CYP (cytochrome P450). It exhibits antitumor, antiviral, and antidepressive activities, and can induce apoptosis.
- Inhibits PKC (protein kinase C)
- Inhibits MAO (monoaminoxidase)
- Inhibits dopamine-beta-hydroxylase
- Inhibits reverse transcriptase
- Inhibits telomerase
- Inhibits CYP (cytochrome P450)
- Shows antitumor activity
- Shows antiviral activity
- Shows antidepressive activity
- Induces apoptosis
- Relevant for infection research
- Relevant for neurological disease research
- Relevant for cancer research
AdipoGen Hypericin
Chemical. CAS 548-04-9. Formula C30H16O8. MW 504.5. Isolated from Hypericum perforatum. One of the principal active constituents of St. Johns Wort Hypericum perforatum. Hypericin is a photosensitive pigment/chromophore with bright red fluorescence emission lambdamax 594nm. Has a high triplet quantum yield and ability to produce considerable amounts of singlet oxygen and other ROS species when photoactivated. Antiviral, anticancer and antidepressant agent. Inactivates enveloped viruses including HIV. This photosensitizing agent has shown to induce apoptosis and necrosis in cancer cells during photodynamic therapy. Selective inhibitor of protein kinase C PKC. Has been shown to inhibit other kinases and targets such as EGFR-PTK, PI3K, CKII, MAPK and insulin receptor IR. Necrosis-avid contrast agent investigated for use in non-invasively targeting necrotic tissues, based on to be defined components in the phospholipid bilayer.
Medchemexpress LLC Docosahexaenoic acid | 6217-54-5 | 98.8% | 200 MG
Docosahexaenoic acid (DHA) is an omega-3 fatty acid abundantly present in the brain and retina, crucial for development and maintaining normal function. Obtained from fish oil and maternal milk, DHA plays a vital role in cognitive abilities and neurological health.
- Essential for infant brain growth and functional development
- Maintains normal adult brain function
- Improves learning ability and memory
- Required for neural cell proliferation, migration, differentiation, and synaptogenesis
- Unique structure supports effective cell signaling
- Potent RXR ligand, activating RXRα at low micromolar concentrations
- Reduces reference memory errors
- Increases DHA content and DHA/arachidonic acid ratio in brain regions
- Exhibits neuroprotective actions in Parkinson's disease models
Accela Chembio Inc Triphenylene | 25g | 217-59-4 | MFCD00001108 | 97+% | Shelf Life: 900 Days | Light Sensitive
Triphenylene | 25g | 217-59-4 | MFCD00001108 | 97+% | Shelf Life: 900 Days | Light Sensitive
Medchemexpress LLC Aristolochic acid B | 475-80-9 | 311.25 | 5 MG
Aristolochic acid B (Aristolochic Acid II) is an orally active major component of aristolochic acid (AA). It can be isolated from plants of the genus Aristolochica. Aristolochic acid B forms DNA adducts, is mutagenic, and exhibits a greater carcinogenic risk in vivo than Aristolochic acid I.
- Target: DNA alkylator/crosslinker
- Research area: Cancer
- Mechanism: Forms DNA adducts and is mutagenic
- Carcinogenic risk: Exhibits greater carcinogenic risk in vivo than Aristolochic acid I
- Appearance: Solid
- Melting/freezing point: 270-272°C
Medchemexpress LLC Aristolochic acid Va | 108779-46-0 | 357.27 | 1 MG
Aristolochic acid Va is a natural compound isolated from *Aristolochia* plants. This high-purity compound is intended for research use only, supporting a wide range of studies in natural product chemistry and biological activity.
- Natural compound isolated from Aristolochia plants.
- Suitable for various research applications.
- High purity for reliable experimental results.
- Available in multiple sizes for research flexibility.
Medchemexpress LLC Aristolochic acid D | 17413-38-6 | 357.27 | 5 MG
Aristolochic acid D | 17413-38-6 | 357.27 | 5 MG
Medchemexpress LLC Aristolochic acid D (Aristolochic acid-IVa) | 17413-38-6 | 357.27 | 1 MG
Aristolochic acid D (Aristolochic acid-IVa) is an orally active PDE2 and CDK2 inhibitor isolated from *Aristolochia indica L.* It exhibits anti-inflammatory activity and can be used in the research of inflammation and tumor-related diseases.
- Orally active PDE2 inhibitor
- Orally active CDK2 inhibitor
- Isolated from *Aristolochia indica L.*
- Exhibits anti-inflammatory activity
- Non-carcinogenic
- Non-nephrotoxic
- Can be used in inflammation research
- Can be used in tumor-related diseases research