Phenanthrenes and derivatives
eMolecules Chem-Impex Malonic acid anhydrous 25kg 272385283 02873 0 000 141-82-2 104 061 C3H4O4
Chem-Impex Malonic acid anhydrous 25kg 272385283 02873 0 000 141-82-2 104 061 C3H4O4
Medchemexpress LLC BCR-ABL1-IN-1 | 1488090-21-6 | 99.8% | C18H12F3N3O2 | 50 MG
BCR-ABL1-IN-1 is an inhibitor for ABL1 (64-515) with an IC50 of 8.7 nM. It can be used in research on diseases related to the central nervous system (CNS). It inhibits the proliferation of Ba/F3-BCR-ABL1-WT cells with an IC50 of 30 nM. This product is for research use only and not sold to patients.
- Inhibits ABL1 (64-515) with an IC50 of 8.7 nM.
- Can be used in research on diseases related to the central nervous system (CNS).
- Inhibits the proliferation of Ba/F3-BCR-ABL1-WT cells with an IC50 of 30 nM.
- Molecular weight is 359.30.
- Appears as a solid, white to off-white in color.
eMolecules Apollo Scientific US - Building Blocks Hexakis(2 2 3 3-tetrafluoropropoxy)phosphazene 250mg 398010245 PC0874 0 000 58943-98-9 MFCD00798140 921 240 C18H18F24N3O6P3
Apollo Scientific US - Building Blocks Hexakis(2 2 3 3-tetrafluoropropoxy)phosphazene 250mg 398010245 PC0874 0 000 58943-98-9 MFCD00798140 921 240 C18H18F24N3O6P3
Medchemexpress LLC Vilazodone hydrochloride | 163521-08-2 | 100.7% | C26H28ClN5O2 | 200 MG
Vilazodone hydrochloride is a serotonin transporter (SER) inhibitor and 5-HT1A receptor partial agonist. This product is for research use only.
- Serotonin transporter (SER) inhibitor
- 5-HT1A receptor partial agonist
- Ships at room temperature
- Store at 4°C, sealed, away from moisture
- In solvent, store at -80°C for 6 months or -20°C for 1 month, sealed, away from moisture
Medchemexpress LLC BCR-ABL1-IN-1 | 1488090-21-6 | 99.8% | C18H12F3N3O2 | 25 MG
BCR-ABL1-IN-1 (Example 74) is an inhibitor for ABL1 (64-515) with an IC50 of 8.7 nM. It demonstrates antiproliferative activity against mouse BaF3 cells expressing BCR-ABL, showing a GI50 of 69 nM and an IC50 of 75 nM. Furthermore, BCR-ABL1-IN-1 inhibits the proliferation of Ba/F3-BCR-ABL1-WT cells with an IC50 of 30 nM. This compound can be utilized in research concerning diseases related to the central nervous system (CNS).
- Inhibitor for ABL1 (64-515) with an IC50 of 8.7 nM
- Shows antiproliferative activity against mouse BaF3 cells expressing BCR-ABL
- Inhibits proliferation of Ba/F3-BCR-ABL1-WT cells
- Suitable for research on diseases related to the central nervous system (CNS)
Medchemexpress LLC Docosahexaenoic acid | 6217-54-5 | 98.8% | 200 MG
Docosahexaenoic acid (DHA) is an omega-3 fatty acid abundantly present in the brain and retina, crucial for development and maintaining normal function. Obtained from fish oil and maternal milk, DHA plays a vital role in cognitive abilities and neurological health.
- Essential for infant brain growth and functional development
- Maintains normal adult brain function
- Improves learning ability and memory
- Required for neural cell proliferation, migration, differentiation, and synaptogenesis
- Unique structure supports effective cell signaling
- Potent RXR ligand, activating RXRα at low micromolar concentrations
- Reduces reference memory errors
- Increases DHA content and DHA/arachidonic acid ratio in brain regions
- Exhibits neuroprotective actions in Parkinson's disease models
eMolecules Key Organics/BIONET Malonic acid 5mg 564178358 STR00614 95 000 141-82-2 104 061 C3H4O4
Key Organics/BIONET Malonic acid 5mg 564178358 STR00614 95 000 141-82-2 104 061 C3H4O4
eMolecules Key Organics/BIONET Malonic acid 50mg 564178360 STR00614 95 000 141-82-2 104 061 C3H4O4
Key Organics/BIONET Malonic acid 50mg 564178360 STR00614 95 000 141-82-2 104 061 C3H4O4
Medchemexpress LLC Prazosin (hydrochloride) | 19237-84-4 | 99.9% | 200 MG
Prazosin hydrochloride is a well-tolerated, CNS-active α1-adrenergic receptor antagonist. It is utilized in research for high blood pressure and alcohol use disorders. The compound effectively inhibits Norepinephrine (NE)-stimulated 45Ca efflux with an IC50 of 0.15 nM and also inhibits organic cation transporters OCT-1 and OCT-3 with IC50s of 1.8 and 13 μM, respectively.
- Acts as a CNS-active α1-adrenergic receptor antagonist
- Used in research for high blood pressure
- Used in research for alcohol use disorders
- Potently inhibits Norepinephrine (NE)-stimulated 45Ca efflux
- Inhibits organic cation transporters OCT-1 and OCT-3
Medchemexpress LLC Amorolfine hydrochloride | 78613-38-4 | 99.6% | 200 MG
Amorolfine hydrochloride (Standard) is an analytical standard and a potent anti-fungal agent that inhibits ergosterol biosynthesis. It is intended for research and analytical applications, with potential for the research of Neoscytalidium dimidiatum onychomycosis.
- Inhibits ergosterol biosynthesis
- Possesses fungistatic and fungicidal activity
- Effective against dermatophyte fungi, filamentous fungi, pathogenic yeasts, dimorphic fungi, and dematiaceous fungi
- Used in qualitative, quantitative, and methodological research experiments such as HPLC, GC, and MS
Medchemexpress LLC Vardenafil hydrochloride trihydrate | 330808-88-3 | 99.7% | 200 MG
Vardenafil hydrochloride trihydrate is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5) with an IC50 of 0.7 nM. It shows inhibitory effects towards PDE1 and PDE6 with IC50s of 180 nM and 11 nM, respectively, while IC50s are >1000 nM for PDE3 and PDE4. It competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis, which increases cGMP levels. It can be used for research related to erectile dysfunction, hepatitis, and diabetes.
- It is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5).
- It has an IC50 of 0.7 nM for PDE5.
- It inhibits PDE1 and PDE6 with IC50s of 180 nM and 11 nM.
- It competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis.
- It increases cGMP levels.
- It can be used for the research of erectile dysfunction.
- It can be used for the research of hepatitis.
- It can be used for the research of diabetes.
Medchemexpress LLC Methacycline hydrochloride | 3963-95-9 | 99.3% | 200 MG
Methacycline hydrochloride is a tetracycline antibiotic that inhibits bacterial protein synthesis. It is also a potent epithelial-mesenchymal transition (EMT) inhibitor, blocking EMT in vitro and fibrogenesis in vivo without directly affecting TGF-β1 Smad signaling. This compound is an antimicrobial and has potential for pulmonary fibrosis.
- Inhibits bacterial protein synthesis
- Acts as a potent epithelial-mesenchymal transition (EMT) inhibitor
- Blocks EMT in vitro and fibrogenesis in vivo
- Demonstrates antimicrobial properties
- Shows potential for pulmonary fibrosis treatment
- Inhibits A549 EMT with an IC50 of approximately 5 μM
- Attenuates Bleomycin-induced canonical EMT markers
- Improves survival at Day 17 in vivo studies
Medchemexpress LLC Vardenafil hydrochloride | 224785-91-5 | 99.8% | 200 MG
Vardenafil hydrochloride is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5) with an IC50 of 0.7 nM, showing lower inhibition of PDE1, PDE6, PDE3, and PDE4. It competitively inhibits cGMP hydrolysis, leading to increased cGMP levels. It is used for research of erectile dysfunction, hepatitis, and diabetes.
- Specifically inhibits cGMP hydrolysis by PDE5, increasing intracellular cGMP levels for increased dilation and blood flow.
- Exhibits facilitator effects in rats with cavernous nerve injury.
- Protects the liver against Con A-induced hepatitis in mice and decreases NF-κB expression.
- Prevents reduction of tissue cGMP levels and increased 3-NT generation in ZDF hearts.
Apexbio Technology LLC IM-12 1129669-05-1 200mg
IM-12 (CAS 1129669-05-1) is a small-molecule inhibitor targeting glycogen synthase kinase-3 (GSK-3 ) displaying an IC50 of 53 nM GSK-3 is a serine/threonine kinase involved in neuronal development energy metabolism and Wnt/ -catenin signaling In ReNcell VM cells IM-12 inhibits GSK-3 resulting in increased -catenin accumulation enhanced TCF transcriptional activity and elevated neuronal differentiation markers The compound also extends cell doubling time and suppresses proliferation These properties make IM-12 valuable for investigating GSK-3 signaling in neurobiology cell proliferation and differentiation studies
Medchemexpress LLC SKF 38393 hydrochloride | 62717-42-4 | MFCD00069248 | >98.0% | 291.77 g/mol | C16H18ClNO2 | 200MG
SKF 38393 hydrochloride is the hydrochloride salt of SKF-38393, a selective dopamine D1 receptor agonist with a reported IC50 of approximately 110 nM. Supplied as a research-grade solid analytical standard, it is used for in vitro pharmacology, receptor binding, and analytical assays. Not for human or clinical use.
- Selective D1 receptor agonist, reported IC50 ≈ 110 nM.
- Hydrochloride salt form improves solubility for biological assays.
- Molecular weight 291.77 g/mol.
- Chemical formula C16H18ClNO2.
- Provided as a solid analytical standard suitable for in vitro studies.
- Typical purities reported ≥98% by HPLC from third-party suppliers.
- Not for human or clinical use; for research only.